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DoD Amyotrophic Lateral Sclerosis Research Program Funding Opportunities

May 9, 2017 08:03 AM
 

Defense Health Program
Department of Defense Amyotrophic Lateral Sclerosis Research Program

Funding Opportunities for Fiscal Year 2017

 

FY17 ALSRP Program Announcements and General Application Instructions for the following award mechanisms posted on the Grants.gov website. 

As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency, Research, Development and Acquisition (DHA RDA) Directorate manages the Defense Health Program (DHP) Research, Development, Test and Evaluation (RDT&E) appropriation.  The managing agent for the anticipated Program Announcement/Funding Opportunity is the Congressionally Directed Medical Research Programs (CDMRP).

Therapeutic Development Award –Pre-application due June 9, Full Application August 31

Independent investigators at all academic levels

Pre-application is required; full application submission is by invitation only.

Supports post-discovery, preclinical development of therapeutics for ALS

Preliminary data, including identify and purity of an identified bioactive compound(s), are required

Types of efforts that will be supported include:

o   Validation of lead pharmacological agents up to IND submission

o   Optimization of potency and pharmacology, studies of formulation, stability and production methods based on Good Manufacturing Practices

Collaboration with industry is encouraged

Clinical trials are not allowed

Does not support screening or development of screens or models

Maximum funding of $1,000,000 for direct costs (plus indirect costs)

Maximum period of performance is years

 

Therapeutic Idea Award – Pre-application due June 9, Full application due August 31

Independent investigators at all academic levels

Pre-application is required; application submission is by invitation only.

Supports hypothesis-driven drug discovery efforts focused on ALS therapeutics

Preliminary data are not required

Types of efforts that will be supported include:

o   Novel exploitation of pathways known to be relevant to ALS for the purpose of improving treatment and/or advancing a novel treatment modality

o   Development, validation and use of novel of high-throughput screens and model systems based on novel targets or innovative drug systems

o   Development of methods for measuring engagement of mechanistic targets by drug candidates

Innovation in technologies and techniques is an important criteria

Maximum funding of $500,000 for direct costs (plus indirect costs)

Maximum period of performance is 2 yearsCharacterization of mechanisms for the purpose of identifying new targets is outside of the scope of this announcement

 

A pre-application is required and must be submitted through the CDMRP electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline.

 

Full applications must be submitted through the federal government's single-entry portal, Grants.gov. All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from Grants.gov. The application package containing the required forms for each award mechanism can be found on Grants.gov. A listing of all CDMRP funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the ALSRP or other CDMRP administered programs, please visit the CDMRP website(http://cdmrp.army.mil).


Point of Contact:

CDMRP Public Affairs
301-619-9783
usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil

 

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